Research Topics
Research Topics
Research Interests
Models coupling metabolic and mutation models with transport are being constructed for the growth of malignant tumors in homo sapiens. These models are significantly more comprehensive than other cancer simulation models reported in the literature. These models are used to assess the effects of chemotherapy and incomplete tumor removal on each of the distinct populations of cancer cells in the vicinity of the tumor, and for the development of optimal cancer treatment strategies.
Many pharmaceutical and biotechnology applications require the formation of high quality crystals from solution. We are developing an integrated approach to control crystal formation that incorporates simulation models, dynamic optimization, and state-of-the-art analysis. This approach includes (i) simulating the nucleation, growth, and aggregation of crystals including the effects of micro- and macromixing, (ii) utilizing video microscopy, laser backscattering, and Raman spectroscopy for the in-situ measurement of the size, shape, and polymorphism of crystals during crystal formation, (iii) analyzing the sensitivity of the states and product quality variables to model uncertainties, and (iv) designing algorithms to control the properties of the product crystals.
Key Words Pharmaceuticals, Peptides, Polymorphism, Image Analysis, Crystallization, Laser Backscattering, ATR-FTIR Spectroscopy, Raman Spectroscopy, Video Microscopy, Optimization, Simulation
Current Research Funding
National Science Foundation; Merck
Foundation, Singapore Agency for Science, Technology, and Research