Research TopicsDepartment of Physiology & Biophysics
Ph.D. (1972) University of Pennsylvania
Research Topics
Research Interests
We use nucleardmagnetic resonance spectroscopy (NMRS) and spectroscopic imaging to study the relation between metabolism and function in living systems as simple as cells in culture and as complex as human subjects. In isolated tissues we study basic problems such as control of ion pumps and channels and metabolic pathways.. Non-invasive studies in animals and humans include mapping of the distribution of metabolites in skeletal muscle and brain, studies of developmental changes and of the metabolic effects of activity in these tissues.
In each case, we are using NMRS techniques for studying specific processes within the context of a complete living system. The aims are to validate new NMRS methods, to elucidate tissue-specific mechanisms and to draw conclusions concerning basic concepts and design in tissue metabolism and function.
Key Words Animal Cell and/or Tissue Culture, Neurobiology, NMR
Current Research Funding
NIH